M2 macrophages contribute to cell proliferation and migration of breast cancer

Breast cancer is a kind of malignant tumor that severely threatens women's lives and health worldwide. Tumor-associated macrophages (TAMs) have been reported to mediate progression, while the mechanism still needs further identification. In this study, we found M2 promoted increased cell proliferation migration as well reduced expression interferon regulatory factor 7 (IRF7) miR-1587 in breast cells. Overexpression IRF7 or knockdown reversed macrophage-induced growth vivo. Mechanistically, targeted 3ʹ-untranslated region (3ʹ-UTR) mRNA regulate its protein leading progression. Collectively, study revealed miR-1587/IRF7 axis mediates sheds light on clinical therapy for by targeting TAMs axis.